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I'm not sure I understand you correctly, but the basic question that Keyes poses was also formulated by neurologist Oliver Sacks in the book “Awakening”. Is the disease part of the individual and will treatment not lead to the loss of any facet of the individual and, accordingly, to even more sad consequences? In particular, Sachs reflects a lot on this in his other books (“The Man who Mistook his Wife for a hat”). Blind people who have regained their sight cannot find new directions in life, and a person who has been cured of Tourette's syndrome has lost their emotionality and self-confidence. Charlie Gordon, being smarter, is not happier, kinder, or stronger. The price of a short-term flash of intelligence is the most severe regression. Perhaps this means that sometimes the disease is not only a part of our life and “has its own unique meaning”, but also a formative component of our unique personality, and the norm is an elusive and difficult to define concept)