2 Answers

  1. Heroin withdrawal in particularly advanced cases, sometimes the final stages of cancer, when the pain can be reduced to a tolerable level, but not completely removed. And yes, there is some particularly severe migraine, most often congenital, which is very difficult to cope with any painkiller.

  2. As an example-psychological trauma.
    For example, phantom pain in amputated limbs. The pain is unlikely to be relieved by painkillers in fact, because there are no limbs in practice.
    At the same time, if the person is sure that it will help-it will help. Even if it's a sugar capsule.

    There is also a headache from which no painkillers help… I do not remember what it is called, the phenomenon is very, very rare and the only thing that can help is LSD, which is prohibited even for use in medicine.

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