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Brain cells gradually die off, the tissue itself does not last forever, even with the use of stem cells, it is impossible to maintain the brain in a normal state for so long. Therefore, cyborgs will not be able to exist in the future.
Solution: creating an electronic model of consciousness based on brain slices and transferring consciousness to an electronic carrier, but this is fantastic.
But another interesting question is that even if the brain could exist forever, if you remove all these brain changes over time, after what time would the person himself get tired of existing – in 200, 500, 1000 years? Knowing all the information over the years and having visited all points of the globe, a person would simply get tired of existing forever. When there is an overabundance of information, after how many years does the brain finally get tired? Another thing is if this person is a scientist, he would not have enough and 1000 years, because he spends all eternity in the peace of truth, and having discovered new patterns, he continues to explore the whole world further.
With hypoxia, our brain dies first, it is enough to squeeze the carotid arteries for 4-5 minutes and that's all, the” shelf life ” of the brain has expired, although all other organs, under similar conditions, can “live” much longer.
But if, let's say, hypothetically, we have created ideal conditions for brain functioning: excellent (!) circulation of all the arteries and veins that serve the brain; the presence in the blood of all the necessary components (and there are a lot of them) for the normal functioning of nerve cells and their regeneration; the absence of all harmful components without exception (there are also a lot of them); daily give the brain the necessary information for development and “improvement”, and maintain these conditions for a long period of time, as it seems to me, the “shelf life” of the brain throughout this time will not expire. That is, the “shelf life” of the brain, in fact, is quite large and it's not about the nervous system and the brain with its “shelf life”, it's about the “conditions” in which they function. Accordingly, if we learn to artificially create and maintain these conditions (if!), then the” shelf life ” of the brain, and not only that, will increase.